The United Nations Population Fund (UNFPA) and United Nations Children’s Fund (UNICEF) Global Programme to End Child Marriage (the ‘Global Programme’) aims to achieve catalytic effects, and works with many partners to advocate for and support practical actions to end child marriage and promote gender equality and the empowerment of adolescent girls. This technical note builds on the technical note on gender transformative approaches; it promotes a common understanding of key concepts and provides practical guidance on how to promote adolescent girls’ empowerment through life skills, including comprehensive sexuality education (CSE). This note is evidence-based and informed by promising practices from the Global Programme and its partners and allies.