Escalating conflict has driven large-scale displacement and exacerbated the already dire humanitarian situation in Cabo Delgado Province in Mozambique. Conflict-related violence, including sexual violence, has intensified. The country also grapples with climate-related disasters, including twin cyclones Kenneth and Idai in 2019, massive flooding in 2020 and cyclone Eloise in early 2021, all of which have left major damage. High numbers of COVID-19 cases compound existing needs. Key components of UNFPA’s response include provision of gender-based violence services and support for mobile sexual and reproductive health brigades to reach the most inaccessible populations.